Publications Choose Therapeutic Area All Areas Cardio-renal-metabolic (2) Drug Discovery (2) Hepatobiliary (7) Neurodegenerative (1) Search Publications Found 12 Results July 2025 An ABCB11 variant registry and novel knockin mouse model of PFIC2 based on the clinically relevant ABCB11 E297G variant Read More June 2025 A Positive Functional Modulator of ABCC6 Decreases Vascular Calcification and Improves Kidney Function in a Rat Adenine Diet Model of Chronic Kidney Disease Read More May 2025 Novel dual-acting ABCB4/MDR3 and ABCB11/BSEP positive functional modulator demonstrates anti-cholestatic and anti-cholangitis activity in two orthogonal models of hepatobiliary disease Read More November 2024 ABCB4/MDR2 Haploinsufficiency Predisposes Mice to Biliary Injury and Secondary Cholestasis and Defines a Translational Model of Toxic Bile Induced Hepatobiliary Injury in Human Cholangiopathy Read More November 2024 Identification and In Vitro Characterization of a Novel BSEP and ABCB4 Dual-Acting Positive Functional Modulator Targeting The Treatment of a Broad Range of Hepatobiliary Diseases Read More November 2024 Identification and in vitro characterization of novel ABCD1 positive functional modulators for the treatment of X-linked adrenoleukodystrophy Read More October 2024 A Positive Functional Modulator of ABCC6 decreases vascular calcification and improves kidney function in a rat adenine diet model Read More July 2024 Characterization of cholestasis in a knock-in BSEPE297G PFIC2 mouse model Read More 12»
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