Publications Choose Therapeutic Area All Areas Cardio-renal-metabolic (2) Drug Discovery (2) Hepatobiliary (9) Neurodegenerative (1) Search Publications Found 15 Results May 2026 Abcb4 Haploinsufficiency Sensitises Mice toa Diet-Induced PSC-Like Hepatobiliary Phenotype WithGallstone Formation Read More May 2026 RTY-406 is a dual-acting ABCB4/MDR3 and ABCB11/BSEP positive functional modulator that demonstrates efficacy in a model of Primary Sclerosing Cholangitis Read More May 2026 RTY-406, a candidate drug for Primary Sclerosing Cholangitis (PSC), a dual-acting ABCB4/MDR3 and ABCB11/BSEP positive functional modulator, demonstrates proof of mechanism in non-human primates Read More July 2025 An ABCB11 variant registry and novel knockin mouse model of PFIC2 based on the clinically relevant ABCB11 E297G variant Read More June 2025 A Positive Functional Modulator of ABCC6 Decreases Vascular Calcification and Improves Kidney Function in a Rat Adenine Diet Model of Chronic Kidney Disease Read More May 2025 Novel dual-acting ABCB4/MDR3 and ABCB11/BSEP positive functional modulator demonstrates anti-cholestatic and anti-cholangitis activity in two orthogonal models of hepatobiliary disease Read More November 2024 ABCB4/MDR2 Haploinsufficiency Predisposes Mice to Biliary Injury and Secondary Cholestasis and Defines a Translational Model of Toxic Bile Induced Hepatobiliary Injury in Human Cholangiopathy Read More November 2024 Identification and In Vitro Characterization of a Novel BSEP and ABCB4 Dual-Acting Positive Functional Modulator Targeting The Treatment of a Broad Range of Hepatobiliary Diseases Read More 12»
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