Publications Choose Therapeutic Area All Areas Cardio-renal-metabolic (2) Drug Discovery (2) Hepatobiliary (6) Neurodegenerative (1) Search Publications Found 11 Results June 2025 A Positive Functional Modulator of ABCC6 Decreases Vascular Calcification and Improves Kidney Function in a Rat Adenine Diet Model of Chronic Kidney Disease Read More May 2025 Novel dual-acting ABCB4/MDR3 and ABCB11/BSEP positive functional modulator demonstrates anti-cholestatic and anti-cholangitis activity in two orthogonal models of hepatobiliary disease Read More November 2024 ABCB4/MDR2 Haploinsufficiency Predisposes Mice to Biliary Injury and Secondary Cholestasis and Defines a Translational Model of Toxic Bile Induced Hepatobiliary Injury in Human Cholangiopathy Read More November 2024 Identification and In Vitro Characterization of a Novel BSEP and ABCB4 Dual-Acting Positive Functional Modulator Targeting The Treatment of a Broad Range of Hepatobiliary Diseases Read More November 2024 Identification and in vitro characterization of novel ABCD1 positive functional modulators for the treatment of X-linked adrenoleukodystrophy Read More October 2024 A Positive Functional Modulator of ABCC6 decreases vascular calcification and improves kidney function in a rat adenine diet model Read More July 2024 Characterization of cholestasis in a knock-in BSEPE297G PFIC2 mouse model Read More March 2024 A structural and mechanistic model for BSEP dysfunction in severe cholestastic disease Read More 12»
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