Associate Director, Translational Sciences

Rectify Pharmaceuticals is focused on delivering life-changing therapies to people with serious ABC transporter mediated diseases. We have built a breakthrough ABC transporter product platform that is enabling efficient and rapid discovery of first-in-class small molecule therapies that restore and enhance ABC transporter function for rare and common liver, biliary, eye, CNS, and cardiometabolic diseases. Rectify believes that the untapped potential of the ABC transporter proteome, in combination with our scientifically validated approach, represents a significant opportunity to address the medical needs of numerous underserved patient communities. Rectify is a privately held Series A company located in Cambridge, MA.

This is an exciting opportunity to join a highly collaborative translational science team and contribute to Rectify’s ABC transporter positive functional modulator (PFM) platform and internal pipeline. This role will have high impact across the Rectify portfolio and provide end-to-end value by contributing to the drug development lifecycle from indication/target nomination, through translational proof of mechanism/concept and into preclinical development. You will gain and deploy deep disease expertise and translational understanding of ABC transporter target function in support of a rich pipeline of programs covering multiple disease areas, including liver, CNS and ophthalmology. You will have tactical, technical, and operational oversight for the execution of Rectify’s translational science strategy leveraging both internal and external stakeholders to deliver de-risking data to inform DC nomination, IND enabling activities and clinical development. You will be responsible for conceptualizing and developing in vitro and in vivo disease models and biomarker strategies in support of multiple programs. In this fast-paced and highly collaborative environment you will engage an expert internal lab-based team of researchers, high-quality CROs and a network of KOLs, consultants and strategic partners. You will deliver and experience real value, influence the strategy of the company, and develop your own career. This role offers a unique chance to stretch your talent and grow your potential.

The successful candidate is an exceptional scientific thinker and operator with a strong background in translational drug discovery and development, and demonstrable evidence of success. You are a self-starter, comfortable and excited to work across multiple therapeutic areas and to develop a deep expertise in ABC transporter biology. You are creative, team-orientated and organized, with strong communication skills.

Essential Functions:

  • Capitalize on your research expertise and your comfort with new areas of biology to identify and champion new mechanistically rationalized indication opportunities
  • Innovate and drive development of disease specific in vivo translational models and PK/PD models to support core pipeline programs and inform clinical development path
  • Design, initiate and manage CRO supported in vivo pharmacology activities
  • Contribute to the design and development of creative fit-for-purpose in vitro assays to support the arc of drug discovery
  • Drive program execution through efficient management and coordination of external in vivo CROs and the delivery of timely and high-quality data
  • Identify, engage and collaborate with leading scientific and clinical KOLs to bring critical insights to our target nomination and development strategy
  • Represent the company and establish credibility amongst external stakeholders including physician and patient communities

Qualifications and Experience:


  • A PhD in a core biology discipline including, but not limited to, molecular and cellular biology, human genetics, translational sciences, or physiology
  • A proven scientific leader with at least 10 years of experience in research and >5 years in drug discovery and in vivo pharmacology
  • Demonstrable experience in successful management of CRO partners for the delivery of critical path initiatives
  • Experience in the design and development of translational in vivo and in vitro disease models
  • High-level presentation skills for scientific communication and reporting at all levels of an organization including senior leadership
  • An innovative and self-motivated approach, driven to find and cultivate value creating opportunities


  • Familiarity with neurological/neurodegenerative and/or retinal disease states and models
  • Experience in biomarker identification and assay development
  • An understanding and experience of rare genetic disease drug development
  • An entrepreneurial mindset and comfort with multitasking and dynamics of small start-up environment

Rectify Pharmaceuticals strives to create and maintain a diverse working environment providing equal employment opportunities to all employees and applicants without regard to race, color, religion, sex, sexual orientation, gender, gender identity or expression, national origin, age, veteran status, disability, genetics or any other factors prohibited by law.

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